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lüll Interferon regulatory factor 4 and 8 in B-cell development Lu RTrends Immunol 2008[Oct]; 29 (10): 487-92Interferon regulatory factor 4 (IRF4) and 8 are members of the interferon regulatory factor family of transcription factors and have been shown to be essential for the development and function of T cells, macrophages and dendritic cells. A series of recent studies have further demonstrated critical functions for IRF4 and 8 at several stages of B-cell development including pre-B-cell development, receptor editing, germinal center reaction and plasma cell generation. Collectively, these new studies provide molecular insights into the function of IRF4 and 8 and underscore a requirement for IRF4 and 8 throughout B-cell development. This review focuses on the recent advances on the roles of IRF4 and 8 in B-cell development.|Animals[MESH]|B-Lymphocytes/*immunology/metabolism[MESH]|Cell Differentiation/immunology[MESH]|Gene Rearrangement, B-Lymphocyte/immunology[MESH]|Humans[MESH]|Ikaros Transcription Factor/immunology/*metabolism[MESH]|Immunoglobulin Class Switching/immunology[MESH]|Interferon Regulatory Factors/immunology/*metabolism[MESH]|Interleukin-7/immunology/metabolism[MESH]|Plasma Cells/*immunology/metabolism[MESH]|Proto-Oncogene Proteins c-bcl-6/immunology/metabolism[MESH] |