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lüll The lens capsule Danysh BP; Duncan MKExp Eye Res 2009[Feb]; 88 (2): 151-64The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both the structure and biomechanics of the lens in addition to providing informational cues to maintain lens cell phenotype. This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.|Accommodation, Ocular[MESH]|Animals[MESH]|Basement Membrane/metabolism[MESH]|Biomechanical Phenomena[MESH]|Cell Membrane Permeability[MESH]|Extracellular Matrix Proteins/metabolism[MESH]|Extracellular Matrix/metabolism[MESH]|Eye Diseases/metabolism/physiopathology[MESH]|Female[MESH]|Humans[MESH]|Lens Capsule, Crystalline/embryology/metabolism/*physiology[MESH]|Organogenesis/physiology[MESH]|Pregnancy[MESH]|Signal Transduction/physiology[MESH] |