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lüll Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy Azmi AS; Mohammad RMJ Cell Physiol 2009[Jan]; 218 (1): 13-21A critical regulator of the apoptotic machinery is the Bcl-2 family proteins whose over expression confers a protective effect on malignant cells against death signals of apoptosis. Cancer cells that are resistant to various anti-cancer drugs and treatment regimen are found to over express these Bcl-2 proteins such as Bcl-2, Bcl-X(L), Mcl-1, Bcl-w, and A1/Bfl1. In recent years there has been an exponential growth in the identification as well as synthesis of non-peptidic cell permeable small-molecule inhibitors (SMIs) of protein-protein interaction. The focus of this article is on inhibitors of anti-apoptotic protein Bcl-2. This review summarizes an up to date knowledge of the available SMIs, their mode of action as well as their current status in preclinical as well as clinical development.|Aniline Compounds/pharmacology[MESH]|Animals[MESH]|Apoptosis/drug effects/physiology[MESH]|Benzamides/pharmacology[MESH]|Binding Sites[MESH]|Biphenyl Compounds/pharmacology[MESH]|Gossypol/analogs & derivatives/pharmacology[MESH]|Humans[MESH]|Indoles[MESH]|Lymphoma/drug therapy[MESH]|Models, Molecular[MESH]|Neoplasms/*drug therapy/pathology/physiopathology[MESH]|Nitrophenols/pharmacology[MESH]|Piperazines/pharmacology[MESH]|Protein Structure, Tertiary[MESH]|Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors/chemistry/classification/physiology[MESH]|Pyrroles/pharmacology[MESH]|Sulfonamides/pharmacology[MESH]|Sulfones/pharmacology[MESH] |