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lüll Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric Gproteins Roychowdhury S; Rasenick MMFEBS J 2008[Oct]; 275 (19): 4654-63Heterotrimeric Gproteins participate in signal transduction by transferring signals from cell surface receptors to intracellular effector molecules. Gproteins also interact with microtubules and participate in microtubule-dependent centrosome/chromosome movement during cell division, as well as neuronal differentiation. In recent years, significant progress has been made in our understanding of the biochemical/functional interactions between Gprotein subunits (alpha and betagamma) and microtubules, and the molecular details emerging from these studies suggest that alpha and betagamma subunits of Gproteins interact with tubulin/microtubules to regulate the assembly/dynamics of microtubules, providing a novel mechanism for hormone- or neurotransmitter-induced rapid remodeling of cytoskeleton, regulation of the mitotic spindle for centrosome/chromosome movements in cell division, and neuronal differentiation in which structural plasticity mediated by microtubules is important for appropriate synaptic connections and signal transmission.|Cell Differentiation[MESH]|Cell Division[MESH]|Cytoskeleton/*metabolism[MESH]|GTP-Binding Protein alpha Subunits, Gi-Go/physiology[MESH]|GTP-Binding Protein alpha Subunits, Gs/physiology[MESH]|GTP-Binding Protein beta Subunits/physiology[MESH]|GTP-Binding Protein gamma Subunits/physiology[MESH]|Heterotrimeric GTP-Binding Proteins/*physiology[MESH]|Microtubules/*physiology[MESH]|Neurons/cytology[MESH]|Signal Transduction[MESH]|Spindle Apparatus/physiology/ultrastructure[MESH]|Tubulin/physiology[MESH] |