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lüll Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I Okajima F; Sato K; Kimura TEndocr J 2009[]; 56 (3): 317-34Plasma high-density lipoprotein (HDL) is a potent anti-atherogenic factor, a critical role of which is thought to be reverse cholesterol transport through the lipoprotein-associated apolipoprotein A-I (apoA-I). HDL also carries a potent bioactive lipid mediator, sphingosine 1-phophate (S1P), which exerts diverse physiological and pathophysiological actions in a variety of biological systems, including the cardiovascular system. In addition, HDL-associated apoA-I is known to stimulate intracellular signaling pathways unrelated to transporter activity. Mounting evidence indicates that multiple antiatherogenic or anti-inflammatory actions of HDL independent of cholesterol metabolism are mediated by the lipoprotein-associated S1P through S1P receptors and by apoA-I through scavenger receptor class B type I.|Animals[MESH]|Apolipoprotein A-I/metabolism[MESH]|Atherosclerosis/*prevention & control[MESH]|Cardiovascular System/drug effects[MESH]|Endothelial Cells/drug effects/physiology[MESH]|Humans[MESH]|Lipoproteins, HDL/*blood[MESH]|Lysophospholipids/metabolism[MESH]|Receptors, Lysosphingolipid/*metabolism[MESH]|Scavenger Receptors, Class B/*physiology[MESH]|Signal Transduction[MESH]|Sphingosine/analogs & derivatives/metabolism[MESH] |