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Role of LKB1 in lung cancer development Makowski L; Hayes DNBr J Cancer 2008[Sep]; 99 (5): 683-8Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation.|AMP-Activated Protein Kinase Kinases[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Lung Neoplasms/*genetics/pathology[MESH]|Mutation[MESH]|Protein Serine-Threonine Kinases/genetics/*physiology[MESH] |