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lüll MHC and MHC-like molecules: structural perspectives on the design of molecular vaccines Apostolopoulos V; Yuriev E; Lazoura E; Yu M; Ramsland PAHum Vaccin 2008[Nov]; 4 (6): 400-9Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors. Recognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC. The MHCs are divided into three subgroups: MHC class I, MHC class II and MHC class III. In addition, non-classical MHC molecules and MHC-like molecules play a pivotal role in shaping our understanding of the immune response. In the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.|Histocompatibility Antigens/*chemistry/*immunology/metabolism[MESH]|Humans[MESH]|Models, Molecular[MESH]|Protein Structure, Tertiary[MESH]|Receptors, Antigen, T-Cell/metabolism[MESH]|Vaccines, Synthetic/*genetics/*immunology[MESH] |