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Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newborn Kumpel BMClin Exp Immunol 2008[Oct]; 154 (1): 1-5For 40 years prophylactic anti-D has been given to D-negative women after parturition to prevent haemolytic disease of the fetus and newborn. Monoclonal or recombinant anti-D may provide alternatives to the current plasma-derived polyclonal IgG anti-D, although none of them have yet proved as effective in phase 1 clinical trials. The variation in efficacy of the antibodies may have been influenced by heterogeneity in glycosylation of anti-D produced from different cell lines. Some aspects of the conduct of the human studies, most notably the use of low doses of anti-D and target D positive red cells in vivo, may aid the design of the clinical development of other immunomodulatory drugs in order to minimize adverse effects.|Clinical Trials as Topic[MESH]|Erythroblastosis, Fetal/*prevention & control[MESH]|Female[MESH]|Fetus/immunology[MESH]|Humans[MESH]|Infant, Newborn/*immunology[MESH]|Isoantibodies/*administration & dosage[MESH]|Pregnancy/*immunology[MESH]|Rh Isoimmunization/*drug therapy[MESH]|Rh-Hr Blood-Group System/*immunology[MESH]|Rho(D) Immune Globulin[MESH] |
