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Macrophage phenotype and renal fibrosis in obstructive nephropathy Nishida M; Hamaoka KNephron Exp Nephrol 2008[]; 110 (1): e31-6Macrophages have classically been recognized as key players that may promote renal fibrosis. However, several recent studies have suggested a beneficial anti-fibrotic role of infiltrating macrophages that acts to preserve renal architecture in the progressive renal scarring associated with obstructive nephropathy. Furthermore, recent investigations indicate a role for macrophages in both inflammation and repair during disease processes and this has superseded the classical injurious view of macrophages. As a result, the exact role of interstitial macrophages upon various facets of renal fibrosis is an important challenge that needs to be addressed. In this article, we discuss the possible beneficial anti-fibrotic role of infiltrating macrophages in obstructive nephropathy and discuss the potential mechanisms that may regulate the effect of macrophages upon renal interstitial fibrosis.|Animals[MESH]|Fibrosis[MESH]|Humans[MESH]|Kidney Diseases/pathology[MESH]|Kidney/*pathology[MESH]|Macrophages/*pathology[MESH]|Phenotype[MESH]|Ureteral Obstruction/*pathology[MESH] |
