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lüll Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention Kim WU; Sreih A; Bucala RAutoimmun Rev 2009[Jan]; 8 (3): 204-8Recent experimental and clinical studies have placed new emphasis on the role of the innate immune system in SLE. Nucleic acid-containing immune complexes activate the innate response by engaging specific Toll-like receptors (TLRs) and promote the generation of autoantibodies. Pharmacologic modulation of TLR-directed pathways may offer new therapeutic approaches for the treatment of SLE.|Animals[MESH]|Autoantibodies/*blood[MESH]|CpG Islands/immunology[MESH]|Homeostasis[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Interferon-alpha/metabolism[MESH]|Lupus Erythematosus, Systemic/blood/*immunology/therapy[MESH]|Mice[MESH]|Reactive Oxygen Species[MESH]|Ribonucleoproteins, Small Nuclear/immunology/*metabolism[MESH]|Self Tolerance[MESH]|Signal Transduction/immunology[MESH]|Toll-Like Receptor 7/immunology/*metabolism[MESH]|Toll-Like Receptor 9/immunology/*metabolism[MESH] |