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Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer Akkiprik M; Feng Y; Wang H; Chen K; Hu L; Sahin A; Krishnamurthy S; Ozer A; Hao X; Zhang WBreast Cancer Res 2008[]; 10 (4): 212The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.|*Gene Expression Regulation, Neoplastic[MESH]|Animals[MESH]|Breast Neoplasms/*diagnosis/*pathology[MESH]|Cell Proliferation[MESH]|Female[MESH]|Humans[MESH]|Insulin-Like Growth Factor Binding Protein 5/*metabolism[MESH]|Insulin-Like Growth Factor Binding Proteins/metabolism[MESH]|Medical Oncology/methods[MESH]|Mice[MESH]|Prognosis[MESH]|Protein Structure, Tertiary[MESH]|Transcription, Genetic[MESH] |
