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The Na-K-ATPase and calcium-signaling microdomains Tian J; Xie ZJPhysiology (Bethesda) 2008[Aug]; 23 (ä): 205-11The Na-K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into transmembrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na-K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na-K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules, including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na+. This review focuses on the unique properties of the Na-K-ATPase and its role in the formation of different calcium-signaling microdomains.|Animals[MESH]|Calcium Signaling/*physiology[MESH]|Cell Compartmentation/*physiology[MESH]|Epithelial Cells/*enzymology[MESH]|Humans[MESH]|Sodium-Potassium-Exchanging ATPase/*metabolism[MESH] |
