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lüll Role of tissue factor disulfides and lipid rafts in signaling Pendurthi UR; Rao LVThromb Res 2008[]; 122 Suppl 1 (Suppl 1): S14-8Tissue factor (TF) is a cellular receptor for coagulation factor VIIa (FVIIa), and the assembly of TF:FVIIa complexes on cell surfaces not only triggers the coagulation cascade but also transduces cell signaling via activation of protease-activated receptors. This brief review summarizes recent controversial data on the importance of protein disulfide isomerase-mediated disulfide bond switching in extracellular domain of TF in regulating its coagulant and cell-signaling activities. The review also discusses the importance of TF localization in lipid rafts and caveolae in maintaining its coagulant and signaling functions.|*Signal Transduction[MESH]|Blood Coagulation/physiology[MESH]|Caveolae/metabolism[MESH]|Cell Membrane/*metabolism[MESH]|Disulfides/*metabolism[MESH]|Forecasting[MESH]|Humans[MESH]|Membrane Microdomains/*metabolism[MESH]|Protein Disulfide-Isomerases/metabolism[MESH]|Thromboplastin/*chemistry/metabolism/physiology[MESH] |