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lüll Role of C-Peptide in the regulation of microvascular blood flow Forst T; Kunt T; Wilhelm B; Weber MM; Pfutzner AExp Diabetes Res 2008[]; 2008 (ä): 176245During the recent years, the role of C-peptide, released from the pancreatic beta cell, in regulating microvascular blood flow, has received increasing attention. In type 1 diabetic patients, intravenous application of C-peptide in physiological concentrations was shown to increase microvascular blood flow, and to improve microvascular endothelial function and the endothelial release of NO. C-peptide was shown to impact microvascular blood flow by several interactive pathways, like stimulating Na(+)K(+)ATPase or the endothelial release of NO. There is increasing evidence, that in patients with declining beta cell function, the lack of C-peptide secretion might play a putative role in the development of microvascular blood flow abnormalities, which go beyond the effects of declining insulin secretion or increased blood glucose levels.|Blood Flow Velocity/*physiology[MESH]|C-Peptide/*physiology[MESH]|Diabetes Mellitus, Type 1/complications/physiopathology[MESH]|Diabetic Angiopathies/physiopathology[MESH]|Endothelium, Vascular/physiology/physiopathology[MESH]|Erythrocyte Deformability/physiology[MESH]|Humans[MESH]|Microcirculation/*physiology[MESH]|Nitric Oxide/physiology[MESH] |