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lüll Cell penetrating peptide inhibitors of nuclear factor-kappa B Orange JS; May MJCell Mol Life Sci 2008[Nov]; 65 (22): 3564-91The nuclear factor kappa B (NF-kappaB) transcription factors are activated by a range of stimuli including pro-inflammatory cytokines. Active NF-kappaB regulates the expression of genes involved in inflammation and cell survival and aberrant NF-kappaB activity plays pathological roles in certain types of cancer and diseases characterized by chronic inflammation. NF-kappaB signaling is an attractive target for the development of novel anti-inflammatory or anti-cancer drugs and we discuss here how the method of peptide transduction has been used to specifically target NF-kappaB. Peptide transduction relies on the ability of certain small cell-penetrating peptides (CPPs) to enter cells, and a panel of CPP-linked inhibitors (CPP-Is) has been developed to directly inhibit NF-kappaB signaling. Remarkably, several of these NF-kappaB-targeting CPP-Is are effective in vivo and therefore offer exciting potential in the clinical setting.|*Models, Biological[MESH]|Amino Acid Sequence[MESH]|Carrier Proteins/*metabolism[MESH]|Cell Survival/physiology[MESH]|Gene Expression Regulation/*physiology[MESH]|I-kappa B Kinase/*metabolism[MESH]|Molecular Sequence Data[MESH]|NF-kappa B/*antagonists & inhibitors[MESH]|Peptides/genetics/*metabolism[MESH]|Signal Transduction/*physiology[MESH] |