suck pdf from google scholar
unlimited free pdf from europmc18660675    free
PDF from PMC    free
html from PMC    free
PDF vom PMID18660675  :  Publisher
PDF vom PMID18660675
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text

  • DeepDyve
  • Pubget Overpricing

  • lüll
  • Therapeutic targets in focal and segmental glomerulosclerosis
  • Lavin PJ; Gbadegesin R; Damodaran TV; Winn MP
  • Curr Opin Nephrol Hypertens 2008[Jul]; 17 (4): 386-92
  • PURPOSE OF REVIEW: Focal and segmental glomerulosclerosis occurs due to a defect in the glomerular filtration barrier. This review highlights contributions from the past year that have enhanced our understanding of the pathophysiology of focal and segmental glomerulosclerosis with emphasis on discoveries which may lead to the identification of therapeutic targets. RECENT FINDINGS: Slit diaphragm proteins have become increasingly important in signal transduction and in mediating downstream events. Actin polymerization occurs after the podocin-nephrin-Neph-1 complex is phosphorylated by Src kinase and Fyn. Recent studies of angiotensin receptor antagonists, corticosteroids and erythropoietin unravel new mechanisms that ameliorate proteinuria by targeting the cell cycle within the podocyte. The discovery that an N-acetylmannosamine kinase (MNK) mutant mouse has glomerulopathy is suggestive that human sialylation pathways may represent therapeutic targets. Proteinuria before podocyte effacement demonstrated in laminin-beta2 null mice highlights the importance of the glomerular basement membrane. Interferon-beta reduced proteinuria in three models of kidney injury, showing greatest effect on glomerular endothelial cells in vitro. SUMMARY: Basic research has illuminated mechanisms by which classic therapies have antiproteinuric effects directly on the podocyte. As knowledge expands with improved molecular techniques, understanding signaling pathways in health and proteinuric states should lead to potential therapeutic targets in focal and segmental glomerulosclerosis.
  • |Actins/physiology[MESH]
  • |Animals[MESH]
  • |Cell Membrane/physiology[MESH]
  • |Cytoskeleton/pathology[MESH]
  • |Glomerulosclerosis, Focal Segmental/*drug therapy/pathology[MESH]
  • |Humans[MESH]
  • |Kidney Glomerulus/pathology[MESH]
  • |Podocytes/pathology[MESH]
  • |Proteinuria/metabolism[MESH]

  • *{{pmid18660675}}
    *<b>[ Therapeutic targets in focal and segmental glomerulosclerosis ]</b> Curr Opin Nephrol Hypertens 2008; 17(4) ; 386-92 Lavin PJ; Gbadegesin R; Damodaran TV; Winn MP


    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    Curr Opin Nephrol Hypertens

    386 4.17 2008