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Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy Oh U; Jacobson SNeurol Clin 2008[Aug]; 26 (3): 781-97, ix-xThe treatment of HAM/TSP is a challenge. No agent has shown to significantly modify the long-term disability associated with HAM/TSP. Advances in our understanding of the pathogenesis of HAM/TSP have led to the identification of several biomarkers and therapeutic targets. Clinical trials in HAM/TSP continue to be opportunities for further qualification and refinement of biomarkers and therapeutic targets. The validation of HAM/TSP relevant biomarkers and the identification of new targets remain key challenges in the development of effective targeted therapy in HAM/TSP.|Astrocytes/pathology/virology[MESH]|Brain/pathology/virology[MESH]|Diagnosis, Differential[MESH]|Disease Progression[MESH]|Drug Therapy/*methods[MESH]|Humans[MESH]|Nerve Degeneration/pathology[MESH]|Paraparesis, Tropical Spastic/*diagnosis/*drug therapy/transmission[MESH]|Polymerase Chain Reaction[MESH]|Risk Factors[MESH]|Spinal Cord/pathology[MESH] |
