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lüll Advances in and applications of proteasome inhibitors Moore BS; Eustaquio AS; McGlinchey RPCurr Opin Chem Biol 2008[Aug]; 12 (4): 434-40With the recent US Food and Drug Administration approval of bortezomib (Velcade) for the treatment of relapsed multiple myeloma, the proteasome has emerged as a new therapeutic target with diverse pathology. Drug discovery programs in academia and the pharmaceutical industry have developed a range of low nanomolar synthetic and natural inhibitors of the 20S proteasome core particle that have entered human clinical trials as significant anti-cancer and anti-inflammatory leads. Moreover, proteasome inhibitors continue to serve as valuable research tools in cellular biology through the elucidation of important biological processes associated with the ubiquitin-proteasome pathway of protein degradation. This review will highlight recent advances in the development and application of proteasome inhibitors.|*Proteasome Inhibitors[MESH]|Drug Design[MESH]|Drug Evaluation, Preclinical[MESH]|Enzyme Inhibitors/chemistry/*pharmacology/*therapeutic use[MESH]|Humans[MESH] |