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lüll Comparative genomics of the mycobacteriophages: insights into bacteriophage evolution Hatfull GF; Cresawn SG; Hendrix RWRes Microbiol 2008[Jun]; 159 (5): 332-9The recognition of the vast numbers of bacteriophages in the biosphere has prompted a renewal of interest in understanding their morphological and genetic diversity, and elucidating the evolutionary mechanisms that give rise to them. We have approached these questions by isolating and characterizing a collection of mycobacteriophages that infect a common bacterial host, Mycobacterium smegmatis. Comparative genomic analysis of 50 mycobacteriophages shows that they are highly diverse, although not uniformly so, that they are pervasively mosaic with a multitude of single gene modules, and that this mosaicism is generated through illegitimate recombination.|*Evolution, Molecular[MESH]|*Genome, Viral[MESH]|Amino Acid Sequence[MESH]|Molecular Sequence Data[MESH]|Mosaicism[MESH]|Mycobacteriophages/*genetics[MESH]|Mycobacterium smegmatis/ultrastructure/*virology[MESH]|Recombination, Genetic[MESH] |