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Human natural killer cells Caligiuri MABlood 2008[Aug]; 112 (3): 461-9Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the innate immune system because unlike T or B lymphocytes of the adaptive or antigen-specific immune system, NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration. During the past 2 decades there has been a substantial gain in our understanding of what and how NK-cells "see," lending important insights into their functions and purpose in normal immune surveillance. The most recent discoveries in NK-cell receptor biology have fueled translational research that has led to remarkable results in treating human malignancy.|Cytotoxicity, Immunologic[MESH]|Humans[MESH]|Immunologic Surveillance[MESH]|Immunophenotyping[MESH]|Interferon-gamma/biosynthesis[MESH]|Killer Cells, Natural/cytology/*immunology[MESH]|Transplantation Immunology[MESH] |
