Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Ion channels that control fertility in mammalian spermatozoa Navarro B; Kirichok Y; Chung JJ; Clapham DEInt J Dev Biol 2008[]; 52 (5-6): 607-13Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSlo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.|*Fertilization[MESH]|*Sperm Motility[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Calcium/metabolism[MESH]|Female[MESH]|Fertility[MESH]|Humans[MESH]|Ion Channels/*chemistry/*physiology[MESH]|Ions/*metabolism[MESH]|Male[MESH]|Molecular Sequence Data[MESH]|Potassium/chemistry[MESH]|Protein Conformation[MESH]|Spermatozoa/*metabolism[MESH] |