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lüll Regulating the acrosome reaction Florman HM; Jungnickel MK; Sutton KAInt J Dev Biol 2008[]; 52 (5-6): 503-10The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction. Here, we discuss the mechanism by which ZP3 generates Ca2+ entry, as well as the upstream events leading to this influx and downstream processes that couple it with exocytosis.|*Acrosome Reaction[MESH]|Animals[MESH]|Calcium Channels/metabolism[MESH]|Calcium/*metabolism[MESH]|Egg Proteins/metabolism[MESH]|Exocytosis[MESH]|Female[MESH]|Glycoproteins/metabolism[MESH]|Humans[MESH]|Male[MESH]|Membrane Glycoproteins/metabolism[MESH]|Mice[MESH]|Models, Biological[MESH]|Receptors, Cell Surface/metabolism[MESH]|Signal Transduction[MESH]|Spermatozoa/*metabolism[MESH]|Zona Pellucida Glycoproteins[MESH]|Zona Pellucida/metabolism[MESH] |