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  • Autoimmunity in the immune privileged eye: pathogenic and regulatory T cells
  • Caspi R
  • Immunol Res 2008[]; 42 (1-3): 41-50
  • Experimental autoimmune uveitis (EAU) in animals serves as a model of human uveitis. EAU can be induced in mice by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP) in complete Freund's adjuvant (CFA) or by IRBP-pulsed mature dendritic cells, and can be driven either by a Th17 or a Th1 effector response, depending on the model. The direction of the response is affected by conditions present during the exposure to antigen, including the quality/quantity of innate receptor stimulation and/or type of APC. IL-17 and IFN-gamma production by innate cells such as NKT may also affect the disease process. If exposure to antigen is via a hydrodynamic DNA vaccination with an IRBP-encoding plasmid, the response is directed to a regulatory phenotype, and disease is ameliorated or prevented. Our data shed light on effector and regulatory responses in autoimmune disease, provide balance to the Th1/Th17 paradigm and help to explain the clinical heterogeneity of human uveitis, which occurs in the face of responses to the same ocular antigen(s).
  • |Animals[MESH]
  • |Autoimmune Diseases/*immunology/metabolism/pathology[MESH]
  • |Eye Proteins/immunology[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/metabolism[MESH]
  • |Interleukin-17/metabolism[MESH]
  • |Retinol-Binding Proteins/immunology[MESH]
  • |T-Lymphocytes, Regulatory/*immunology[MESH]
  • |T-Lymphocytes/*immunology/metabolism[MESH]
  • |Th1 Cells/immunology/metabolism[MESH]
  • |Uveitis/*immunology/metabolism/pathology[MESH]





  • *{{pmid18629448}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=18629448 Autoimmunity in the immune privileged eye: pathogenic and regulatory T cells ]</b> Immunol Res 2008; 42(1-3) ; 41-50 Caspi R

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    Immunol Res

    41 1-3.42 2008