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RLIP76 and Cancer Awasthi S; Singhal SS; Awasthi YC; Martin B; Woo JH; Cunningham CC; Frankel AEClin Cancer Res 2008[Jul]; 14 (14): 4372-7RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds.|ATP-Binding Cassette Transporters/genetics/*metabolism[MESH]|GTPase-Activating Proteins/genetics/*metabolism[MESH]|Humans[MESH]|Neoplasms/*metabolism[MESH]|Oxidative Stress/physiology[MESH]|Signal Transduction/*physiology[MESH] |
