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Synaptic vesicle fusion Rizo J; Rosenmund CNat Struct Mol Biol 2008[Jul]; 15 (7): 665-74The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion. In addition, SNARE complex assembly is likely orchestrated by Munc13s and RIMs, active-zone proteins that function in vesicle priming and diverse forms of presynaptic plasticity. Synaptotagmin-1 mediates triggering of release by Ca2+, probably through interactions with SNAREs and both membranes, as well as through a tight interplay with complexins. Elucidation of the release mechanism will require a full understanding of the network of interactions among all these proteins and the membranes.|Animals[MESH]|Membrane Fusion/*physiology[MESH]|Munc18 Proteins/chemistry/metabolism[MESH]|Nerve Tissue Proteins/chemistry/metabolism[MESH]|SNARE Proteins/chemistry/metabolism[MESH]|Synaptic Vesicles/*metabolism[MESH]|Synaptotagmin I/chemistry/metabolism[MESH] |
