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lüll Pheochromocytoma: current approaches and future directions Adler JT; Meyer-Rochow GY; Chen H; Benn DE; Robinson BG; Sippel RS; Sidhu SBOncologist 2008[Jul]; 13 (7): 779-93Pheochromocytomas are rare catecholamine-secreting tumors that arise from chromaffin tissue within the adrenal medulla and extra-adrenal sites. Because of the excess secretion of hormones, these tumors often cause debilitating symptoms and a poor quality of life. While medical management plays a significant role in the treatment of pheochromocytoma patients, surgical excision remains the only cure. Improved medical management and surgical techniques and an increased understanding of hereditary disease have improved the outcome of pheochromocytoma patients with benign disease; however, the outcome of patients with malignant disease remains poor. In this review, we discuss the presentation, diagnosis, management, and future directions in the management of this disease.|*Adrenal Gland Neoplasms/diagnosis/genetics/therapy[MESH]|*Pheochromocytoma/diagnosis/genetics/therapy[MESH]|Adrenal Glands/surgery[MESH]|Chemotherapy, Adjuvant[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Neoplasm Metastasis/prevention & control[MESH]|Radiotherapy, Adjuvant[MESH] |