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lüll Signal-induced repression: the exception or the rule in developmental signaling?Affolter M; Pyrowolakis G; Weiss A; Basler KDev Cell 2008[Jul]; 15 (1): 11-22Cell-cell communication plays a key role in organ formation and patterning in multicellular animals and is carried out by a few evolutionarily conserved signaling pathways. The modes of action of these pathways share a number of general properties, or habits, that allow them to strongly activate target genes in a ligand-dependent manner in the proper cellular contexts. Recent studies have revealed that some developmental signaling pathways can also strongly repress genes in a ligand-dependent manner. These new findings raise the interesting possibility that this repressive mode of action is shared by many or most developmental signaling pathways.|*Gene Expression Regulation, Developmental[MESH]|*Gene Silencing[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Cell Communication[MESH]|Embryo, Nonmammalian[MESH]|Ligands[MESH]|Models, Biological[MESH]|Transcription Factors/genetics[MESH]|Transcription, Genetic[MESH]|Transcriptional Activation[MESH] |