Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Genetic polymorphism and variability of chemical carcinogenesis Belitsky GA; Yakubovskaya MGBiochemistry (Mosc) 2008[May]; 73 (5): 543-54Risk assessment in chemical carcinogenesis involves ratios of several factors. Individual responses of an organism to carcinogenic agents depend on polymorphism of enzymes responsible for metabolic activation/detoxification of carcinogens, DNA repair, and apoptosis, as well as promotion and progression in malignantly transformed cells. The effects of a particular polymorphic variant are manifested only in the case of its high penetrance. An integral effect is formed by the ratio of procarcinogenic and anticarcinogenic effects. The complexity of risk assessment depends on the gene polymorphism mosaic involved, directly or indirectly, in tumorigenesis and upstream/downstream interactions of gene products.|*Polymorphism, Genetic[MESH]|Animals[MESH]|Apoptosis/drug effects[MESH]|Carcinogens/chemistry/*toxicity[MESH]|Cell Transformation, Neoplastic/*drug effects/*genetics[MESH]|Cytochrome P-450 Enzyme System/genetics/metabolism[MESH]|DNA Repair Enzymes/genetics/metabolism[MESH]|Humans[MESH]|Mutagens/chemistry/toxicity[MESH] |