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The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche Estes JD; Haase AT; Schacker TWSemin Immunol 2008[Jun]; 20 (3): 181-6The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.|Animals[MESH]|CD4-Positive T-Lymphocytes/cytology/*immunology/pathology[MESH]|Cell Proliferation[MESH]|Collagen/*metabolism[MESH]|Fibrosis/immunology[MESH]|HIV Infections/*immunology/*pathology[MESH]|HIV-1/*immunology/physiology[MESH]|Humans[MESH]|Lymphoid Tissue/immunology/pathology/virology[MESH]|Simian Acquired Immunodeficiency Syndrome/*immunology/pathology[MESH]|Simian Immunodeficiency Virus/*immunology[MESH]|Virus Replication[MESH] |
