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Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid Burri BJ; Dougherty RM; Kelley DS; Iacono JMAm J Clin Nutr 1991[Aug]; 54 (2): 359-62The effect of concentrations of linoleic acid (LA) on platelet aggregation was measured in seven healthy adult males. Subjects were randomly divided into two groups; these groups were fed natural food diets of identical composition except that one was high in LA (11.5% of energy) and low in oleic acid (OA) (7.4% of energy), the other was low in LA (4.5% of energy) and high in OA (15.7% of energy). The thresholds of ADP- and collagen-induced platelet aggregation were increased significantly by the high LA diet even though the intake of total fat and saturated fatty acids did not differ in these diets.|Adenosine Diphosphate/administration & dosage/pharmacology[MESH]|Adult[MESH]|Antithrombin III/metabolism[MESH]|Collagen/administration & dosage/pharmacology[MESH]|Dietary Fats, Unsaturated/administration & dosage/*pharmacology[MESH]|Humans[MESH]|Kinetics[MESH]|Linoleic Acid[MESH]|Linoleic Acids/administration & dosage/*pharmacology[MESH]|Male[MESH]|Oleic Acid[MESH]|Oleic Acids/administration & dosage/*pharmacology[MESH]|Platelet Aggregation/*drug effects[MESH]|Vitamin A/blood[MESH]|Vitamin E/blood[MESH] |
