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Medical treatment as an alternative to adrenalectomy in patients with aldosterone-producing adenomas Karagiannis A; Tziomalos K; Kakafika AI; Athyros VG; Harsoulis F; Mikhailidis DPEndocr Relat Cancer 2008[Sep]; 15 (3): 693-700Primary aldosteronism (PA) and, in particular, its two commonest subtypes (i.e. idiopathic hyperaldosteronism (IHA) and aldosterone-producing adenoma (APA)) have been recognized as the most common cause of secondary hypertension. While 'conservative' medical treatment with aldosterone receptor antagonists is the therapeutic approach of choice in controlling blood pressure in patients with PA due to IHA, the more invasive (laparoscopic) adrenalectomy seems to be the most suitable therapy for patients with APA. In this review, we focus on the medical approach for the management of APA in cases where surgical excision of the adrenal is not possible.|Adrenal Cortex Neoplasms/complications/*drug therapy/metabolism/surgery[MESH]|Adrenalectomy[MESH]|Adrenocortical Adenoma/complications/*drug therapy/metabolism/surgery[MESH]|Aldosterone/metabolism[MESH]|Humans[MESH]|Hyperaldosteronism/drug therapy/etiology[MESH]|Mineralocorticoid Receptor Antagonists/*therapeutic use[MESH] |
