Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The plasticity of gamma delta T cells: innate immunity, antigen presentation and new immunotherapy Casetti R; Martino ACell Mol Immunol 2008[Jun]; 5 (3): 161-70Several signals influence dendritic cell (DC) functions and consequent the immune responses to infectious pathogens. Our recent findings provide a new model of intervention on DCs implicating human gammadelta T cell stimuli. Vgamma9Vdelta2 T cells represent the major subset of circulating human gammadelta T cells and can be activated by non-peptidic molecules derived from different microorganisms or abnormal metabolic routes. With activated-Vgamma9Vdelta2 T cell co-culture, immature DCs acquire features of mature DCs, such as increasing the migratory activity, up-regulating the chemokine receptors, and triggering the Th1 immune response. Similar to the NK-derived signals, DC activation is mediated by soluble factors as well as cell-to-cell contact. Many non-peptidic molecules including nitrogen-containing bisphosphonates and pyrophosphomonoester drugs, can stimulate the activity of Vgamma9Vdelta2 T cells in vitro and in vivo. The relatively low in vivo toxicity of many of these drugs makes possible novel vaccine and immune-based strategies against infectious diseases.|*Antigen Presentation[MESH]|*Immunity, Innate[MESH]|*Immunotherapy[MESH]|Animals[MESH]|Cell Communication[MESH]|Cytokines/immunology/*metabolism[MESH]|Dendritic Cells/*immunology/metabolism/microbiology[MESH]|Humans[MESH]|Lymphocyte Activation[MESH]|Mycobacterium bovis/immunology/physiology[MESH]|Neoplasms/immunology/therapy[MESH]|Receptors, Antigen, T-Cell, gamma-delta/*immunology/metabolism[MESH]|T-Lymphocyte Subsets/*immunology/metabolism[MESH]|Tuberculosis/immunology/therapy[MESH] |