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Regulation of RNA polymerase III transcription by Maf1 protein Ciesla M; Boguta MActa Biochim Pol 2008[]; 55 (2): 215-25Maf1 was the first protein discovered to regulate polymerase III RNA in yeast and because it is evolutionarily conserved, a Maf1 ortholog also serves to restrain transcription in mouse and human cells. Understanding the mechanism of the regulation has been made possible by recent studies showing that Maf1 is a nuclear/cytoplasmic protein whose subcellular distribution and hence negative regulation of Pol III transcription is mediated by the nutrient-sensing signaling pathways, TOR and RAS. Under stress conditions and during growth in a nonfermentable carbon source Maf1 is dephosphorylated and imported to the nucleus. In its non-phosphorylated form, Maf1 interacts with the polymerase III transcription machinery. Phosphorylation serves to locate Maf1 to the cytoplasm under favorable growth conditions, thereby preventing it from non-negatively regulating polymerase III when high levels of tRNA transcription are required. Relocation of Maf1 to the cytoplasm is dependent on Msn5, a carrier responsible for export of several other phosphoproteins out of the nucleus. The absence of Maf1-mediated control of tRNA synthesis impairs yeast viability in nonfermentable carbon sources. Moreover, in cells grown in a nonfermentable carbon source, Maf1 regulates the levels of different tRNAs to various extents. This differential regulation may contribute to the physiological role of Maf1.|Amino Acid Sequence[MESH]|Gene Expression Regulation, Enzymologic[MESH]|Gene Expression Regulation, Fungal[MESH]|Genes, Fungal[MESH]|Mitochondria/metabolism[MESH]|Models, Biological[MESH]|Phosphorylation[MESH]|RNA Polymerase III/*genetics/*metabolism[MESH]|RNA, Fungal/genetics/metabolism[MESH]|RNA, Transfer/genetics/metabolism[MESH]|Saccharomyces cerevisiae Proteins/genetics/*metabolism[MESH]|Saccharomyces cerevisiae/*genetics/*metabolism[MESH]|Signal Transduction[MESH]|Subcellular Fractions/metabolism[MESH]|Transcription Factors/genetics/*metabolism[MESH]|Transcription, Genetic[MESH] |
