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Adipokines--targeting a root cause of cardiometabolic risk Bakhai AQJM 2008[Oct]; 101 (10): 767-76Obesity often co-presents with other cardiometabolic risk factors such as dyslipidaemia, insulin resistance and hypertension. Less well appreciated is that dysregulation of adipokine production by excess adipose tissue also promotes a state of low-level systemic chronic inflammation and a prothrombotic state, implicated in the development of both atherosclerosis and subsequently cardiovascular events. Lifestyle modification and pharmacological therapy can reduce cardiometabolic risk, a benefit that may be partly due to their effects on adipokine levels.|Adipokines/*metabolism[MESH]|Adipose Tissue/metabolism[MESH]|Atherosclerosis/*etiology[MESH]|Cholesterol Ester Transfer Proteins/physiology[MESH]|Diabetes Mellitus, Type 2/etiology/prevention & control[MESH]|Diabetic Angiopathies/etiology[MESH]|Dyslipidemias/*etiology/physiopathology[MESH]|Fatty Liver/etiology[MESH]|Humans[MESH]|Insulin Resistance/*physiology[MESH]|Life Style[MESH]|Obesity/*complications[MESH]|Risk Factors[MESH]|Weight Loss/physiology[MESH] |
