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lüll Regulation of mitochondrial antiviral signaling pathways Moore CB; Ting JPImmunity 2008[Jun]; 28 (6): 735-9Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.|*Signal Transduction[MESH]|Adaptor Proteins, Signal Transducing/immunology/*metabolism[MESH]|Animals[MESH]|Cytokines/*metabolism[MESH]|Humans[MESH]|Interferon Type I/immunology/metabolism[MESH]|Mitochondria/immunology/*metabolism[MESH]|RNA Helicases/*metabolism[MESH]|RNA, Viral/*metabolism[MESH]|Receptors, Pattern Recognition/*metabolism[MESH]|Toll-Like Receptors/metabolism[MESH]|Viruses/*immunology[MESH] |