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lüll Meta-analysis: the outcome of anti-viral therapy in HCV genotype 2 and genotype 3 infected patients with chronic hepatitis Andriulli A; Mangia A; Iacobellis A; Ippolito A; Leandro G; Zeuzem SAliment Pharmacol Ther 2008[Aug]; 28 (4): 397-404BACKGROUND: Anti-viral therapy seems more successful in HCV genotype 2 than genotype 3-infected patients. AIM: To report sustained virological response (SVR) rates for HCV-2 and HCV-3 infection. METHODS: Meta-analyses were carried out on SVR data on 2275 patients treated for 24 weeks in eight individual trials and on 968 patients with rapid virological response (RVR) treated for 12-16 weeks or 24 weeks in four studies. RESULTS: After 24 weeks of therapy, SVR rates were 74% and 68%, respectively, for HCV-2 and HCV-3 genotype patients. Among high viraemics, SVR rate in HCV-2 infection (75%) differed from the 58% value in HCV-3 infection. Among low viraemic patients, respective rates were 79% and 75%. In RVR patients treated for 12-16 or 24 weeks, SVR rates in HCV-2 infection were 83% and 84%, respectively, and in HCV-3 infection 84% and 86%. In patients without RVR treated for 24 weeks, SVR was higher in HCV-2, with a 17.8% weighted difference. CONCLUSIONS: Twenty-four weeks of therapy should remain standard duration for HCV-2 and low viraemic HCV-3 patients. In RVR patients, HCV-3 patients respond to short-treatment as well as HCV-2 patients, irrespective of basal viraemia. Patients without RVR may need longer treatment than the recommended 24 weeks.|Antiviral Agents/*therapeutic use[MESH]|Genotype[MESH]|Hepacivirus/*drug effects/genetics[MESH]|Hepatitis C, Chronic/*drug therapy/genetics[MESH]|Humans[MESH]|Interferon alpha-2[MESH]|Interferon-alpha/*therapeutic use[MESH]|Polyethylene Glycols/*therapeutic use[MESH]|Predictive Value of Tests[MESH]|RNA, Viral/blood/genetics[MESH]|Recombinant Proteins[MESH]|Ribavirin/*therapeutic use[MESH]|Treatment Outcome[MESH] |