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Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid Skowsky WR; Wilf LHSouth Med J 1991[May]; 84 (5): 636-41We have presented a case of sporadic medullary carcinoma of the thyroid with documentation of localization of tracer 131I-MIBG within the primary neoplasm. A review of the nuclear medicine literature of localization techniques for MCT demonstrates that 131I-MIBG, while an excellent choice for diagnosis of pheochromocytoma and neuroblastoma, produces low yield and unpredictable concentration in other neural crest apudomas, including MCT. A low incidence of true-positive results with 131I-MIBG uptake and a high incidence of false-negative results make this radiopharmaceutical a suboptimal choice for diagnostic studies, but a potentially promising one as a therapeutic agent.|*Antineoplastic Agents/therapeutic use[MESH]|*Iodobenzenes/therapeutic use[MESH]|3-Iodobenzylguanidine[MESH]|Aged[MESH]|Carcinoma/*diagnostic imaging/drug therapy[MESH]|Female[MESH]|Humans[MESH]|Iodine Radioisotopes[MESH]|Organotechnetium Compounds[MESH]|Radionuclide Imaging[MESH]|Succimer[MESH]|Technetium Tc 99m Dimercaptosuccinic Acid[MESH]|Thyroid Neoplasms/*diagnostic imaging/drug therapy[MESH]|Tomography, X-Ray Computed[MESH] |
