Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll A putative role of the Amyloid Precursor Protein Intracellular Domain (AICD) in transcription Slomnicki LP; Lesniak WActa Neurobiol Exp (Wars) 2008[]; 68 (2): 219-28Amyloid Precursor Protein (APP) Intracellular Domain (AICD) is the product of APP processing realized by alpha- or beta-secretases and gamma-secretase. It was shown that AICD is able to interact with several proteins which regulate its stability and cellular localization. The Fe65 adaptor protein translocates AICD into nucleus where the APP-Fe65-Tip60 ternary complex may activate transcription of target genes. In the light of recent studies AICD seems to be another product of APP proteolysis endowed with important biological functions that may contribute to Alzheimer's disease pathology.|Amyloid beta-Protein Precursor/*chemistry/*genetics/metabolism[MESH]|Animals[MESH]|Extracellular Fluid/*metabolism[MESH]|Histone Acetyltransferases[MESH]|Humans[MESH]|Lysine Acetyltransferase 5[MESH]|Nuclear Proteins/genetics/*metabolism[MESH]|Protein Structure, Tertiary[MESH]|Transcription, Genetic/*physiology[MESH] |