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  • Regulatory T cells and immune tolerance
  • Sakaguchi S; Yamaguchi T; Nomura T; Ono M
  • Cell 2008[May]; 133 (5): 775-87
  • Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.
  • |*Self Tolerance[MESH]
  • |Animals[MESH]
  • |Autoimmune Diseases/immunology[MESH]
  • |Humans[MESH]
  • |T-Lymphocytes, Regulatory/*immunology[MESH]
  • |Thymus Gland/cytology/immunology[MESH]





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    *<b>[http://www.kidney.de/mlpefetch.php?search=18510923 Regulatory T cells and immune tolerance ]</b> Cell 2008; 133(5) ; 775-87 Sakaguchi S; Yamaguchi T; Nomura T; Ono M

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    Cell

    775 5.133 2008