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The complex role of vitamin D in autoimmune diseases Szodoray P; Nakken B; Gaal J; Jonsson R; Szegedi A; Zold E; Szegedi G; Brun JG; Gesztelyi R; Zeher M; Bodolay EScand J Immunol 2008[Sep]; 68 (3): 261-9Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.|Animals[MESH]|Autoimmune Diseases/blood/diet therapy/*physiopathology[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Immunity, Active[MESH]|Immunity, Innate[MESH]|Mice[MESH]|Receptors, Calcitriol/metabolism[MESH]|Vitamin D Deficiency/*immunology[MESH]|Vitamin D/blood/pharmacology/*physiology/therapeutic use[MESH] |
