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lüll Click chemistry, a powerful tool for pharmaceutical sciences Hein CD; Liu XM; Wang DPharm Res 2008[Oct]; 25 (10): 2216-30Click chemistry refers to a group of reactions that are fast, simple to use, easy to purify, versatile, regiospecific, and give high product yields. While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. In this manuscript, important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications. Bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered. Limitations of the reaction will also be discussed.|*Chemistry, Pharmaceutical[MESH]|*Drug Carriers[MESH]|Alkynes/*chemical synthesis[MESH]|Azides/*chemical synthesis[MESH]|Catalysis[MESH]|Copper/chemistry[MESH]|Cyclization[MESH]|Liposomes[MESH]|Metal Nanoparticles[MESH]|Micelles[MESH]|Models, Chemical[MESH]|Molecular Probes/*chemical synthesis[MESH]|Polymers/*chemical synthesis[MESH]|Technology, Pharmaceutical/*methods[MESH] |