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lüll Lysophospholipid interactions with protein targets Parrill ALBiochim Biophys Acta 2008[Sep]; 1781 (9): 540-6Bioactive lysophospholipids include lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), cyclic-phosphatidic acid (CPA) and alkyl glycerolphosphate (AGP). These lipid mediators stimulate a variety of responses that include cell survival, proliferation, migration, invasion, wound healing, and angiogenesis. Responses to lysophospholipids depend upon interactions with biomolecular targets in the G protein-coupled receptor (GPCR) and nuclear receptor families, as well as enzymes. Our current understanding of lysophospholipid interactions with these targets is based on a combination of lysophospholipid analog structure activity relationship studies as well as more direct structural characterization techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and experimentally-validated molecular modeling. The direct structural characterization studies are the focus of this review, and provide the insight necessary to stimulate structure-based therapeutic lead discovery efforts in the future.|Animals[MESH]|Humans[MESH]|Lysophospholipids/chemistry/*metabolism[MESH]|Models, Molecular[MESH]|Protein Binding[MESH]|Receptors, Cytoplasmic and Nuclear/metabolism[MESH]|Receptors, Lysophospholipid/chemistry/genetics/*metabolism[MESH] |