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lüll Chagas disease cardiomyopathy: current concepts of an old disease Bilate AM; Cunha-Neto ERev Inst Med Trop Sao Paulo 2008[Mar]; 50 (2): 67-74Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy.|Animals[MESH]|Chagas Cardiomyopathy/*etiology/genetics/immunology[MESH]|Chronic Disease[MESH]|Cytokines/*immunology[MESH]|Humans[MESH]|Inflammation/immunology[MESH] |