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Artificial circulation of the liver: machine perfusion as a preservation method in liver transplantation Vekemans K; Liu Q; Pirenne J; Monbaliu DAnat Rec (Hoboken) 2008[Jun]; 291 (6): 735-40Due to the sharp increase in liver transplant candidates and the subsequent shortage of suitable donor livers, an extension of the current donor criteria is necessary. Simple cold storage, the current standard in organ preservation has proven to be insufficient to preserve extended criteria donor livers. Therefore a renewed interest grew toward alternative methods for liver preservation, such as hypothermic machine perfusion and normothermic machine perfusion. These "new" preservation methods were primarily assessed in rat models, and only a few clinically relevant large animal models have been described so far. This review will elaborate on these alternative preservation methods.|*Liver Circulation[MESH]|Animals[MESH]|Dogs[MESH]|Humans[MESH]|Liver Transplantation/*methods[MESH]|Models, Animal[MESH]|Organ Preservation Solutions[MESH]|Organ Preservation/instrumentation/*methods[MESH]|Perfusion/instrumentation/methods[MESH]|Rabbits[MESH]|Rats[MESH]|Sus scrofa[MESH]|Temperature[MESH] |
