Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll LKB1 and lung cancer: more than the usual suspects Shah U; Sharpless NE; Hayes DNCancer Res 2008[May]; 68 (10): 3562-5Often, the problem in cancer research is figuring out how a gene or pathway works in regulating cellular transformation. The question of what RAS activates or PTEN inhibits have been classic dilemmas of modern cancer biology. In these cases, biochemical and genetic studies have provided us with a fairly clear picture of the cancer relevant functions of these genes. For LKB1, a more recently identified human tumor suppressor gene, however, the problem is different. This serine-threonine kinase that is conserved from yeast to mammals seems to play a role in many diverse cellular pathways. Therefore, although elegant functional and genetic approaches have established critical roles for LKB1 in the regulation of metabolism, motility, polarity, and the cell cycle, the role(s) responsible for its true tumor suppressor function(s) is unknown. One is reminded of an Agatha Christie murder mystery where nearly every character in the book has reason to be suspected of committing the crime-there are too many suspects for how LKB1 might repress lung cancer.|*Gene Expression Regulation, Neoplastic[MESH]|AMP-Activated Protein Kinase Kinases[MESH]|AMP-Activated Protein Kinases[MESH]|Aged[MESH]|Animals[MESH]|Genes, Tumor Suppressor[MESH]|Humans[MESH]|Lung Neoplasms/*genetics[MESH]|Mice[MESH]|Models, Biological[MESH]|Models, Genetic[MESH]|Neoplasm Metastasis[MESH]|Protein Serine-Threonine Kinases/*genetics/*physiology[MESH] |