Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases Dubois-Dalcq M; Williams A; Stadelmann C; Stankoff B; Zalc B; Lubetzki CBrain 2008[Jul]; 131 (Pt 7): 1686-700In the central nervous system (CNS) of man, evolutionary pressure has preserved some capability for remyelination while axonal regeneration is very limited. In contrast, two efficient programmes of regeneration exist in the adult fish CNS, neurite regrowth and remyelination. The rapidity of CNS remyelination is critical since it not only restores fast conduction of nerve impulses but also maintains axon integrity. If myelin repair fails, axons degenerate, leading to increased disability. In the human CNS demyelinating disease multiple sclerosis (MS), remyelination often takes place in the midst of inflammation. Here, we discuss recent studies that address the innate repair capabilities of the axon-glia unit from fish to man. We propose that expansion of this research field will help find ways to maintain or enhance spontaneous remyelination in man.|*Nerve Regeneration/drug effects[MESH]|Animals[MESH]|Central Nervous System Diseases/diagnosis/*physiopathology/therapy[MESH]|Demyelinating Diseases/diagnosis/*physiopathology/therapy[MESH]|Disease Models, Animal[MESH]|Fishes[MESH]|Humans[MESH]|Inflammation/physiopathology[MESH]|Magnetic Resonance Imaging/methods[MESH]|Multiple Sclerosis/physiopathology[MESH]|Myelin Sheath/*physiology[MESH]|Neuroprotective Agents/pharmacology[MESH]|Oligodendroglia/physiology[MESH] |
