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Mechanisms of oral tolerance revisited Wang J; Toes REArthritis Res Ther 2008[]; 10 (2): 108Oral tolerance induction is thought to depend on special antigen presenting cells in the gut. A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamine 2,3-dioxygenase-expressing dendritic cells in Peyer's patches from orally tolerized mice suppress T-cell responses via the generation of CD4+CD25+ regulatory T cells. This finding provides novel input into the mechanisms of oral tolerance that could further facilitate its use for the treatment of autoimmunity and chronic inflammatory reactions.|*Immune Tolerance[MESH]|Administration, Oral[MESH]|Animals[MESH]|Antigens/*administration & dosage/immunology[MESH]|Dendritic Cells/enzymology/immunology[MESH]|Humans[MESH]|Indoleamine-Pyrrole 2,3,-Dioxygenase/immunology/metabolism[MESH] |
