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lüll BAFF and the plasticity of peripheral B cell tolerance Stadanlick JE; Cancro MPCurr Opin Immunol 2008[Apr]; 20 (2): 158-61BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.|*Immune Tolerance[MESH]|Animals[MESH]|B-Cell Activating Factor/*metabolism[MESH]|B-Cell Activation Factor Receptor/*metabolism[MESH]|B-Lymphocytes/*immunology[MESH]|Humans[MESH]|Mice[MESH]|Receptors, Antigen, B-Cell/metabolism[MESH]|Signal Transduction[MESH] |