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Biology of infection with Borrelia burgdorferi Tilly K; Rosa PA; Stewart PEInfect Dis Clin North Am 2008[Jun]; 22 (2): 217-34, vThe spirochete Borrelia burgdorferi is a tick-borne obligate parasite whose normal reservoir is a variety of small mammals. Although infection of these natural hosts does not lead to disease, infection of humans can result in Lyme disease as a consequence of the human immunopathologic response to B burgdorferi. Consistent with the pathogenesis of Lyme disease, bacterial products that allow B burgdorferi to replicate and survive seem to be primarily what is required for the bacterium to cause disease in a susceptible host. This article describes the basic biology of B burgdorferi and reviews some of the bacterial components required for infection of and survival in the mammalian and tick hosts.|Animals[MESH]|Arachnid Vectors/microbiology[MESH]|Borrelia burgdorferi/genetics/growth & development/immunology/*physiology[MESH]|Disease Models, Animal[MESH]|Genome, Bacterial[MESH]|Humans[MESH]|Life Cycle Stages[MESH]|Lyme Disease/immunology/*microbiology/transmission[MESH]|Ticks/microbiology[MESH] |
