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Studying gene function in Caenorhabditis elegans using RNA-mediated interference Maine EMBrief Funct Genomic Proteomic 2008[May]; 7 (3): 184-94The RNA interference (RNAi) method for targeted gene silencing is widely used in Caenorhabditis elegans for large-scale functional genomic studies, analysis of limited gene sets and detailed analysis of individual gene function. The application of RNAi has identified genes that participate in various aspects of development, physiology and cell biology. In addition, RNAi has been used to identify interacting genes and to study functionally redundant genes. This review discusses the various applications of RNAi in C. elegans, focusing particularly on the analysis of developmental processes.|*RNA Interference[MESH]|Animals[MESH]|Caenorhabditis elegans Proteins/*genetics/physiology[MESH]|Caenorhabditis elegans/*genetics/physiology[MESH]|Genomics/methods[MESH] |
